Hanada K, Ishikawa H, Tamai K, Hashimoto I, Sato K
Department of Dermatology, Hirosaki University School of Medicine, Japan.
J Dermatol Sci. 1991 Jan;2(1):18-23. doi: 10.1016/0923-1811(91)90038-y.
GST-pi has been known to be markedly increased in human (pre) neoplasms of several organs. In this paper, the significance of immunohistochemical detection of GST-pi in human malignant tumors of the skin was studied. In specimens from 40 patients with various skin cancers, malignant melanoma, Paget's disease and undifferentiated squamous cell carcinoma showed strong reactivity in GST-pi staining. The reactions were negative or weak in Bowen's disease, basal cell epithelioma and solar keratosis. In normal melanocytes, eccrine, apocrine, and breast gland cells stained positively but not in keratinocytes, sebaceus gland and fibroblasts. While immunohistochemical detection of GST-pi in the skin was not specific for malignancies, it contributed to aid the distinction of squamous cell carcinoma from other keratinocytic tumors. GST-pi might provide potentially useful information on chemosensitivity of skin cancer, and might serve as a biomarker of disease activity.
已知谷胱甘肽S转移酶π（GST-pi）在人体多个器官的（癌）前肿瘤中显著增加。本文研究了免疫组织化学检测GST-pi在人类皮肤恶性肿瘤中的意义。在40例患有各种皮肤癌的患者标本中，恶性黑色素瘤、佩吉特病和未分化鳞状细胞癌在GST-pi染色中显示出强反应性。在鲍恩病、基底细胞上皮瘤和日光性角化病中，反应为阴性或弱阳性。在正常黑素细胞、小汗腺、大汗腺和乳腺细胞中染色呈阳性，但在角质形成细胞、皮脂腺和成纤维细胞中则不然。虽然皮肤中GST-pi的免疫组织化学检测对恶性肿瘤不具有特异性，但有助于区分鳞状细胞癌与其他角质形成细胞肿瘤。GST-pi可能提供有关皮肤癌化学敏感性的潜在有用信息，并可能作为疾病活动的生物标志物。
