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5-脂氧合酶、白三烯生物合成及潜在的抗白三烯药物

5-Lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents.

作者信息

Jampilek Josef, Dolezal Martin, Opletalova Veronika, Hartl Jiri

机构信息

Zentiva a.s., U kabelovny 130, 102 37 Prague, Czech Republic.

出版信息

Curr Med Chem. 2006;13(2):117-29. doi: 10.2174/092986706775197935.

DOI:10.2174/092986706775197935
PMID:16472209
Abstract

Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.

摘要

白三烯在呼吸道、胃肠道和皮肤系统过敏性疾病所伴随的炎症过程中发挥着重要作用。白三烯是由花生四烯酸在5-脂氧合酶的作用下生成的。本文探讨了5-脂氧合酶的作用机制以及随后所有白三烯的生物合成过程。在本文中，潜在的抗白三烯药物根据其作用机制进行了分类。捷克共和国布拉格药学与生物化学研究所（VUFB）最初的抗白三烯化合物在本文的单独一章中进行了介绍。

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Curr Med Chem. 2006;13(2):117-29. doi: 10.2174/092986706775197935.
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