Castillo Ana, Liébana José, López Encarnación, Baca Pilar, Liébana José M, Liébana María J, Castillo Francisca
Department of Microbiology, School of Medicine and Dentistry, University of Granada, Spain.
Int J Antimicrob Agents. 2006 Mar;27(3):263-6. doi: 10.1016/j.ijantimicag.2005.10.017. Epub 2006 Feb 13.
The growth curve interference (GCI) induced by different antibiotics was studied using reference strains of oral streptococci. This parameter may prove to be useful in preventing subacute endocarditis of odontological origin in high-risk patients. The growth curves using different concentrations of antibiotics and with an initial optical density (OD) of 0.05 +/- 0.01 were observed until an OD of 0.9-1.0 was reached. The GCI was defined as the lowest concentration of antibiotic that modified the growth curve with respect to a control without antibiotic. The GCI values were then compared with the minimum inhibitory concentration (MIC) values. In all cases, interference in the growth curves was at least one concentration lower than the MIC in a time ranging from 4-6 h.
使用口腔链球菌参考菌株研究了不同抗生素诱导的生长曲线干扰（GCI）。该参数可能被证明对预防高危患者牙源性亚急性心内膜炎有用。观察了使用不同浓度抗生素且初始光密度（OD）为0.05±0.01的生长曲线，直至达到OD为0.9 - 1.0。GCI定义为相对于无抗生素对照改变生长曲线的最低抗生素浓度。然后将GCI值与最低抑菌浓度（MIC）值进行比较。在所有情况下，生长曲线的干扰在4 - 6小时的时间段内至少比MIC低一个浓度。
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