Kravchenko A T, Rodionova V G
Zh Mikrobiol Epidemiol Immunobiol. 1975 Jan(1):29-33.
Administration to guinea pigs of 1/Dlm of diphtheria exotoxin twice at an interval of 1 and 24 hours, or once in a dose of 25/100 Dlm caused changes in the activity of the redox enzymes. The character of their changes in the animals to which the whole dose of the exotoxin was administered once or repeatedly was directly reverse: in the first case the activity of the enzymes was uniformly increased, and in the second--ununiformly depressed; besides, there was a marked disturbance of coordination between the enzymes. An increased sensitivity of the infectious allergy type following injection of low doses of diphtheria exotoxin was not accompanied by immunity formation. Specific antibodies against diphtheria exotoxin formed only in the organism of animals to which 1/100 Dlm of diphtheria toxin was injected once a day for 15 days, but in this case as well no immunity against diphtheria exotoxin was observed.
给豚鼠间隔1小时和24小时两次注射1/100剂量的白喉外毒素，或一次注射25/100剂量的白喉外毒素，会引起氧化还原酶活性的变化。一次或多次给予动物全剂量外毒素后，其酶活性变化的特征正好相反：在第一种情况下，酶活性均匀增加，而在第二种情况下，酶活性不均匀降低；此外，酶之间存在明显的协调性紊乱。注射低剂量白喉外毒素后传染性过敏型敏感性增加，但不伴有免疫形成。仅在每天注射1/100剂量白喉毒素、持续15天的动物体内形成了针对白喉外毒素的特异性抗体，但在这种情况下也未观察到对白喉外毒素的免疫。
