McMahon Chris G
Australian Centre for Sexual Health, Sydney, Australia.
Nat Clin Pract Urol. 2005 Sep;2(9):426-33. doi: 10.1038/ncpuro0293.
Premature ejaculation (PE) is a common male sexual disorder. Normative data suggest that men with an intravaginal ejaculatory latency time of less than 1 min have 'definite' premature ejaculation, while men with intravaginal ejaculatory latency times of between 1 and 1.5 min have 'probable' premature ejaculation. Although there is insufficient empirical evidence to identify the etiology of PE, there is correlational evidence to suggest that men with PE have high levels of sexual anxiety and altered sensitivity of central 5-hydroxytryptamine receptors. Pharmacological modulation of the ejaculatory threshold using daily or on-demand selective serotonin reuptake inhibitors offers patients a high likelihood of achieving improved ejaculatory control within a few days of initiating treatment, leads to improvements in sexual desire and other sexual domains, and is well tolerated.
早泄（PE）是一种常见的男性性功能障碍。规范性数据表明，阴道内射精潜伏期少于1分钟的男性患有“明确的”早泄，而阴道内射精潜伏期在1至1.5分钟之间的男性患有“可能的”早泄。尽管尚无足够的实证证据来确定早泄的病因，但有相关证据表明，早泄男性存在高度性焦虑以及中枢5-羟色胺受体敏感性改变。使用每日或按需服用的选择性5-羟色胺再摄取抑制剂对射精阈值进行药物调节，能使患者在开始治疗后的几天内极有可能改善射精控制能力，还能提高性欲并改善其他性功能领域，且耐受性良好。
