Hada Y
Department of Rehabilitation Medicine, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.
Clin EEG Neurosci. 2006 Jan;37(1):25-9. doi: 10.1177/155005940603700106.
The latencies of SEP N20, P40, N60, P100, and N140 components were measured after stimulation of two different sites, and the differences in relation to conduction velocity and their central functions are discussed. Subjects were 8 healthy right-handed males (age 22-31 years, height 164-184 cm). An electrical pulse of 200micro sec duration with an intensity of 2 times the motor threshold was delivered to the wrist and to the elbow alternately at a random rate of 0.1 to 0.3 Hz. Recording electrodes were Cz', C3', and C4' referenced to linked ears. Analysis time was 50 msec before and 450 msec after the stimulus. The band pass was 0.5 Hz to 2 kHz. Subjects were asked to mentally count the number of stimuli. The averaging was interrupted after every 16 to 24 stimuli and checked to determine whether the subject was attentive to the stimuli by verifying the number of stimuli counted. A total of 100 responses each from elbow and wrist stimuli were averaged. Differences in peak latency between elbow and wrist stimuli for N20, P40, N60, P100, and N140 were 3.7 +/- 0.7 msec, 5.0 +/- 1.8, 4.3 +/- 1.2, 8.1 +/- 6.3, and 7.4 +/- 2.6 msec, respectively. According to the latency differences, SEP components can be divided into 3 groups: the shortest difference for N20, medium difference for P40 and N60 and longest difference for P100 and N140. Similar latency differences and similar potential distribution for P40 and N60, and for P100 and N140, and their differences from N20 confirmed that each of N20, P40/N60, and P100/N140 has a different function centrally. In addition, central processing time was longer with the more distal site stimulation.
在刺激两个不同部位后测量了体感诱发电位（SEP）N20、P40、N60、P100和N140成分的潜伏期，并讨论了与传导速度及其中枢功能相关的差异。受试者为8名健康右利手男性（年龄22 - 31岁，身高164 - 184厘米）。以0.1至0.3赫兹的随机频率，将持续时间为200微秒、强度为运动阈值2倍的电脉冲交替施加于手腕和肘部。记录电极置于Cz'、C3'和C4'，参考电极连接双耳。分析时间为刺激前50毫秒和刺激后450毫秒。带通为0.5赫兹至2千赫兹。要求受试者在心里数刺激次数。每16至24次刺激后中断平均，并通过核对所数刺激次数来检查受试者是否专注于刺激。对来自肘部和手腕刺激的各100个反应进行平均。肘部和手腕刺激在N20、P40、N60、P100和N140的峰值潜伏期差异分别为3.7±0.7毫秒、5.0±1.8、4.3±1.2、8.1±6.3和7.4±2.6毫秒。根据潜伏期差异，SEP成分可分为3组：N20差异最短，P40和N60差异中等，P100和N140差异最长。P40和N60以及P100和N140的潜伏期差异相似、电位分布相似，且它们与N20的差异证实了N20、P40/N60和P100/N140在中枢各有不同功能。此外，刺激部位越远端，中枢处理时间越长。
