Mierau Rudolf, Genth Ekkehard
Rheumaklinik Aachen, Aachen, Germany.
Clin Chem Lab Med. 2006;44(2):138-43. doi: 10.1515/CCLM.2006.026.
Diagnosis of rheumatoid arthritis (RA) is mainly based on clinical criteria of symmetric polyarthritis of the hands and feet, with morning stiffness lasting usually more than 1 h. Autoantibodies typical for RA, i.e., rheumatoid factors and anti-cyclic citrullinated peptide, and measurements of inflammation add more specific information, especially for early diagnosis, where clinical presentation may be oligosymptomatic involving only a few joints. These laboratory parameters are also relevant for prognosis of disease persistence, functional impairment and radiological progression.
类风湿关节炎（RA）的诊断主要基于手足对称性多关节炎的临床标准，晨僵通常持续超过1小时。RA典型的自身抗体，即类风湿因子和抗环瓜氨酸肽，以及炎症指标检测可提供更多特异性信息，尤其是在早期诊断中，此时临床表现可能仅累及少数关节，症状较少。这些实验室指标对于疾病持续、功能损害和放射学进展的预后也具有重要意义。
