Ying S H, Choi S I, Perlman S L, Baloh R W, Zee D S, Toga A W
Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Neurology. 2006 Feb 14;66(3):424-6. doi: 10.1212/01.wnl.0000196464.47508.00.
Spinocerebellar ataxia type 2 (SCA2) has protean manifestations, and a clinical marker of progression is needed. Although MRI is a promising tool, it is unclear whether the degree of atrophy shown on MRI is correlated with clinical dysfunction. Here the authors used high-resolution volumetric MRI analysis to show that cerebellar and pontine volumes specifically and closely correlate with functional staging scores.
2型脊髓小脑共济失调（SCA2）有多种表现形式，因此需要一种疾病进展的临床标志物。虽然磁共振成像（MRI）是一种很有前景的工具，但尚不清楚MRI显示的萎缩程度是否与临床功能障碍相关。在本文中，作者使用高分辨率容积MRI分析表明，小脑和脑桥体积与功能分期评分具有特异性且密切的相关性。
