Wang L, Liang Y
Zhonghua Yi Xue Za Zhi. 1991 Feb;71(2):81-3, 8.
The expression and distribution of the extracellular matrix (ECM) in 37 gliomas and 19 meningiomas were studied immunohistochemically by antibodies to type 3, 4 and 6 collagen, fibronectin and laminin. In gliomas the expression of these antigens was more intense and thicker in the tumor vessel walls, and was positively correlated to the malignant degree of the gliomas. This suggests that the thickening of the vessel walls and the increase of their ECM components in gliomas may be one of the causes why gliomas are extremely rare to metastasize to the outside of the cranium. All the above-cited ECM were positive in the fibroblastic type of meningioma, being just located between the tumor cells; whereas in syncytial type they were negative. This indicates that the immunohistochemistry of ECM may be of advantage in differentiating meningioma type.
通过使用针对Ⅲ型、Ⅳ型和Ⅵ型胶原、纤连蛋白和层粘连蛋白的抗体，采用免疫组织化学方法研究了37例胶质瘤和19例脑膜瘤中细胞外基质（ECM）的表达和分布情况。在胶质瘤中，这些抗原在肿瘤血管壁中的表达更强烈且更厚，并且与胶质瘤的恶性程度呈正相关。这表明胶质瘤中血管壁增厚及其ECM成分增加可能是胶质瘤极少转移至颅外的原因之一。上述所有ECM在纤维母细胞型脑膜瘤中呈阳性，位于肿瘤细胞之间；而在合体细胞型中则为阴性。这表明ECM的免疫组织化学在鉴别脑膜瘤类型方面可能具有优势。
