Hong Seok-Beom, Jin Sheng-Yu, Park Hae-Jeong, Jung Joo-Ho, Sim Woo-Young
Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.
J Korean Med Sci. 2006 Feb;21(1):90-4. doi: 10.3346/jkms.2006.21.1.90.
Monocyte chemoattractant protein-1 (MCP-1) levels are increased in scalp lesions of patients with alopecia areata (AA), suggesting a role in the development of AA. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. We investigated whether the presence of these polymorphisms were associated with AA in Korean population. 145 Korean patients with AA, 246 healthy subjects without clinical evidence of AA were screened for genotype with a PCR-based assay. In the AA patients the frequency of the A and G alleles was 40.3 and 59.7%, respectively and the distribution of the A/A, A/G and G/G genotypes was 19.3, 42.1 and 38.6%, respectively. Amongst the controls the frequency of the A and G alleles was 39.8 and 60.2%, and the distribution of the A/A, A/G, G/G genotypes in the same group was 17.5, 44.7 and 37.8%, respectively. There was no significant difference in the allele frequencies and genotype distributions between the patients and the controls (p=0.889, p=0.848, respectively). Our data indicates that no association exists between the -2518A/G polymorphism of the MCP-1 gene and susceptibility to alopecia areata.
斑秃（AA）患者头皮病变中单核细胞趋化蛋白-1（MCP-1）水平升高，提示其在斑秃发病中起作用。最近，在MCP-1启动子-2518位点发现了一种双等位基因A/G多态性，它会影响MCP-1在炎症刺激下的表达水平。我们研究了这些多态性的存在是否与韩国人群的斑秃有关。采用基于聚合酶链反应（PCR）的检测方法，对145例韩国斑秃患者和246例无斑秃临床证据的健康受试者进行了基因型筛查。在斑秃患者中，A和G等位基因的频率分别为40.3%和59.7%，A/A、A/G和G/G基因型的分布分别为19.3%、42.1%和38.6%。在对照组中，A和G等位基因的频率分别为39.8%和60.2%，同一组中A/A、A/G、G/G基因型的分布分别为17.5%、44.7%和37.8%。患者与对照组之间的等位基因频率和基因型分布无显著差异（p值分别为0.889和0.848）。我们的数据表明，MCP-1基因-２５１８A/G多态性与斑秃易感性之间不存在关联。
