Synthesis and characterization of [186Re]rhenium(V)dimercaptosuccinic acid: a possible tumour radiotherapy agent.
作者信息
Bisunadan M M, Blower P J, Clarke S E, Singh J, Went M J
机构信息
Biological and Chemical Laboratories, The University, Canterbury, Kent.
出版信息
Int J Rad Appl Instrum A. 1991;42(2):167-71. doi: 10.1016/0883-2889(91)90068-c.
PMID:1648035
Abstract
[186Re]Re(V)DMSA, a beta-emitting analogue of the tumour imaging radiopharmaceutical pentavalent [99mTc]Tc(V)DMSA of possible value in tumour therapy, is readily prepared by stannous reduction of [186Re]ReO4 in the presence of dimercaptosuccinic acid at 100 degrees C using a commercial DMSA kit as used for renal imaging with 99mTc, and purified using a disposable sample preparation column. The complex has been identified as [ReO(DMSA)2] by NMR, optical and i.r., spectroscopy and elemental analysis.
摘要
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