Hak E, Buskens E, Nichol K L, Verheij T J M
Julius Center for Health Sciences and Primary Health Care, University Medical Center Utrecht, HP 6.139, P.O. Box 85060, 3508 AB Utrecht, The Netherlands.
Vaccine. 2006 Apr 5;24(15):2799-802. doi: 10.1016/j.vaccine.2006.01.008. Epub 2006 Jan 18.
It is unknown whether a first influenza vaccination protects high-risk adults from severe morbidity and mortality during influenza epidemics. As part of the PRISMA nested case-control study, we aimed to evaluate the effectiveness of first-time and repeat influenza vaccinations in adult persons recommended for vaccination aged between 18 and 64 years during the 1999-2000 influenza A epidemic. After adjustments, 69% of hospitalizations for acute respiratory or cardiovascular disease or death were prevented in first-time vaccinees (95% percent confidence interval [95% CI]: 8-90%). The corresponding figure in persons who were vaccinated before was 85% (95% CI: 36-96%). Adult persons with high-risk medical conditions can substantially benefit from a first and repeat influenza vaccination prior to an epidemic.
首次流感疫苗接种能否保护高危成年人在流感流行期间免于严重发病和死亡尚不清楚。作为PRISMA巢式病例对照研究的一部分，我们旨在评估在1999 - 2000年甲型流感流行期间，首次和重复流感疫苗接种对年龄在18至64岁之间推荐接种疫苗的成年人的有效性。调整后，首次接种疫苗者预防了69%的急性呼吸道或心血管疾病住院或死亡（95%置信区间[95%CI]：8 - 90%）。之前接种过疫苗的人的相应数字为85%（95%CI：36 - 96%）。患有高危疾病的成年人在流感流行前进行首次和重复流感疫苗接种可从中大幅获益。
