CD-1远交系小鼠对恙虫病DNA候选疫苗p47Kp的短期和长期免疫反应
Short- and long-term immune responses of CD-1 outbred mice to the scrub typhus DNA vaccine candidate: p47Kp.
作者信息
Xu Guang, Chattopadhyay Suchismita, Jiang Ju, Chan Teik-Chye, Chao Chien-Chung, Ching Wei-Mei, Richards Allen L
机构信息
Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA.
出版信息
Ann N Y Acad Sci. 2005 Dec;1063:266-9. doi: 10.1196/annals.1355.043.
Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.
恙虫病东方体是一种专性细胞内细菌，是恙虫病的病原体。为了开发一种有效的疫苗来预防或改善恙虫病，需要确定对恙虫病东方体的保护性免疫反应。我们实验室已经证明，携带恙虫病东方体Karp株47-kDa蛋白基因（p47Kp）的DNA疫苗载体pVR1012始终能为远交系小鼠提供针对同源攻击的保护。
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