[Polymorphism of genes of factors of hemostasis in patients with early development of ischemic heart disease.].

The review is devoted to analysis of data, related to contribution of genetic peculiarities of the hemostasis system to early development of ischemic heart disease (IHD). Information is presented on polymorphisms of tissue factor, coagulation factors VII, V, prothrombin, thrombomodulin, fibrinogen, thrombin activated fibrinolysis inhibitor, tissue plasminogen activator inhibitor, platelet membrane glycoproteines Ia, Iba, IIIa in patients with early development of IHD. Contradictoriness of existing data on effects of genetic heterogeneity of factors of hemostasis on risk of development of IHD at young age and necessity of further investigations in this area are underlined.