Adamec R E
Department of Psychology, Memorial University, St. John's, Newfoundland, Canada.
Physiol Behav. 1991 Mar;49(3):443-53. doi: 10.1016/0031-9384(91)90263-n.
This study examined the interictal consequences of partial kindling of the ventral perforant path on attack and defensive behavior in the domestic cat. Partial kindling produced a lasting increase in defense response of cats to both rats and conspecific threat howls. In addition, there was a lasting suppression of approach-attack behaviors directed toward rats. The suppression of some components of approach-attack were shown to be independent of the increases in defensive response. The effects of partial kindling of the ventral perforant path on spread of seizure activity into the amygdala, and on the output of the amygdala to both the ventromedial hypothalamus (VMH) and bed nucleus of the stria terminalis (BNST) were also examined. In addition, the effects of repeated hippocampal seizures on recurrent inhibition in the trisynaptic circuit (areas CA1 and CA3) were investigated. Growth of seizure activity in the amygdala and VMH as partial kindling progressed was essential for behavioral change. In addition, interictal long-term potentiation of potentials evoked in the VMH and in the BNST by pulsed stimulation of the amygdala followed partial kindling or afterdischarge threshold determination in the ventral perforant path. A lasting interictal increase in inhibition in area CA3 and a lasting interictal failure of inhibition in area CA1 of the ventral hippocampus also followed partial kindling. These changes in limbic physiology were related to the behavioral changes produced by partial kindling. The analysis revealed the importance of the amygdalo-VMH pathway in increased defensive response to rats. The amygdalo-BNST pathway is not important in mediating defensive response to prey, but it is implicated in suppression of some types of predatory aggression. Finally, changes in neural inhibition in the ventral hippocampus in areas CA1 and CA3 are associated with changes in both defensiveness and predatory aggression.
本研究考察了家猫腹侧穿通通路部分点燃对发作期及防御行为的影响。部分点燃使猫对大鼠和同种威胁叫声的防御反应持续增强。此外，对大鼠的趋近-攻击行为受到持续抑制。研究表明，趋近-攻击行为某些成分的抑制与防御反应的增强无关。本研究还考察了腹侧穿通通路部分点燃对癫痫活动扩散至杏仁核以及杏仁核对腹内侧下丘脑（VMH）和终纹床核（BNST）输出的影响。此外，还研究了反复海马癫痫发作对三突触回路（CA1区和CA3区）中反复抑制的影响。随着部分点燃的进展，杏仁核和VMH中癫痫活动的增强对行为改变至关重要。此外，在腹侧穿通通路进行部分点燃或测定放电阈值后，杏仁核脉冲刺激诱发的VMH和BNST电位的发作间期长时程增强随之出现。腹侧海马CA3区发作间期抑制的持续增加以及CA1区发作间期抑制的持续缺失也在部分点燃后出现。这些边缘系统生理学变化与部分点燃引起的行为变化相关。分析揭示了杏仁核-VMH通路在增强对大鼠防御反应中的重要性。杏仁核-BNST通路在介导对猎物的防御反应中并不重要，但与某些类型的捕食性攻击的抑制有关。最后，腹侧海马CA1区和CA3区神经抑制的变化与防御性和捕食性攻击的变化相关。
