甲氧氯普胺增强阿司匹林对大鼠的抗血栓形成作用。

Enhancement of antithrombotic effect of aspirin by metoclopramide in rats.

作者信息

Mobarok Ali A T, al-Humayyd M S

机构信息

Department of Medical Pharmacology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Thromb Res. 1991 Feb 15;61(4):361-7. doi: 10.1016/0049-3848(91)90649-h.

DOI:10.1016/0049-3848(91)90649-h

PMID:1648276

Abstract

The potential antithrombotic effect of aspirin and metoclopramide were studied in a model of arterial thrombosis in rats. Thrombosis was produced in the abdominal aorta by the combination of local partial obstruction and intravenous administration of hypotonic saline containing 5-HT. The resulting aortic occlusion and the effects of drugs were quantified by measuring rectal temperature. Metoclopramide as well as ketanserine effectively reversed while zacopride failed to alter thrombotic effect. Metoclopramide or ketanserine when combined with aspirin enhanced the antithrombotic effect of the latter. On the other hand, co-administration of metoclopramide with ketanserine failed to show any synergistic effect. As with ketanserine, the antithrombotic effect of metoclopramide appeared to be mediated through the blockade of 5-HT2 receptors in the platelets.

摘要

在大鼠动脉血栓形成模型中研究了阿司匹林和甲氧氯普胺的潜在抗血栓作用。通过局部部分阻塞并静脉注射含5-羟色胺（5-HT）的低渗盐水，在腹主动脉中形成血栓。通过测量直肠温度对形成的主动脉阻塞及药物作用进行定量。甲氧氯普胺和酮色林可有效逆转血栓形成，而扎考必利未能改变血栓形成效应。甲氧氯普胺或酮色林与阿司匹林联合使用可增强阿司匹林的抗血栓作用。另一方面，甲氧氯普胺与酮色林联合给药未显示出任何协同效应。与酮色林一样，甲氧氯普胺的抗血栓作用似乎是通过阻断血小板中的5-HT2受体介导的。