Niinuma Hiroyuki, Kawazoe Kohei
Cardiovascular Surgery, Memorial Heart Center, Iwate Medical University, Morioka, Japan.
Nihon Geka Gakkai Zasshi. 2006 Jan;107(1):21-6.
Ischemic mitral regurgitation (IMR) is a serious problem, which conveys adverse prognosis, doubling mortality after myocardial infarction. It is common and increases mortality even when mild. IMR is often associated with the occlusion of left circumflex coronary artery, such as second or third obtuse marginal branches by experimental model. However, cause of IMR still remains unclear in many respects. Several study using echocardiography and magnetic resonance imaging show some probable reasons left ventricular structure and deformity of left ventricle may cause mitral leaflet restriction and mitral annulus deformity, lead to tethering. The aim of surgical treatment of IMR is to reduce the grade of mitral regurgitation and left ventricular remodeling. Recent study clarified the advantage of valve repair in IMR opposed to valve replacement that may affect the patient poor quality of life. Some new technique of saddle shaped ring repair, second chordal cutting, edge-to-edge repair are available but these long-term outcome remain unclear. It may be effective combined left ventricular revascularization and mitral valve repair. Understanding mechanism of IMR will improve therapies for targeted primary causes with new therapeutic options provided a more flexible approach for surgical repair of IMR.
缺血性二尖瓣反流(IMR)是一个严重问题,它预示着不良预后,会使心肌梗死后的死亡率翻倍。它很常见,即使程度较轻也会增加死亡率。IMR常与左旋支冠状动脉闭塞有关,如实验模型中的第二或第三钝缘支。然而,IMR的病因在很多方面仍不明确。几项使用超声心动图和磁共振成像的研究显示了一些可能的原因,左心室结构和左心室畸形可能导致二尖瓣叶受限和二尖瓣环畸形,进而导致瓣叶连枷。IMR外科治疗的目的是降低二尖瓣反流程度和左心室重塑。最近的研究阐明了IMR中瓣膜修复相对于瓣膜置换的优势,瓣膜置换可能会影响患者的生活质量。一些新的技术,如鞍形环修复、二次腱索切断、边缘对边缘修复等已经出现,但这些技术的长期效果仍不明确。联合左心室血运重建和二尖瓣修复可能是有效的。了解IMR的机制将改善针对原发性病因的治疗方法,为IMR的手术修复提供更灵活的方法和新的治疗选择。