Masuya Daiki, Liu Dage, Ishikawa Shinya, Yamamoto Yasumichi, Huang Cheng-long, Yokomise Hiroyasu
Second Department of Surgery, Faculty of Medicine, Kagawa University, Japan.
Jpn J Thorac Cardiovasc Surg. 2006 Jan;54(1):31-4. doi: 10.1007/BF02743782.
We experienced a surgical case of large cell carcinoma with neuroendocrine morphology (LCCNM) of the lung. A 76-year-old man was admitted to our hospital because a routine chest X-ray examination had revealed a nodular shadow in the left lung field. 18F-fluorodeoxyglucose positron emission tomography showed accumulation of fluorodeoxyglucose in an area corresponding to the shadow. Transbronchial lung biopsy failed to give a definitive diagnosis, therefore open lung biopsy was performed because of suspected lung cancer. Needle biopsy was performed, and the tumor was diagnosed as large cell neuroendocrine carcinoma by rapid intraoperative pathological examination. As sampling of hilar lymph nodes revealed no metastasis, left upper segmentectomy was performed for severe obstructive pulmonary disease. Immunohistochemical examination finally diagnosed the tumor as LCCNM. The patient is doing well without recurrence at ten months after surgery.
我们遇到了一例具有神经内分泌形态的肺大细胞癌（LCCNM）的外科病例。一名76岁男性因常规胸部X线检查发现左肺野有结节状阴影而入院。18F-氟脱氧葡萄糖正电子发射断层扫描显示氟脱氧葡萄糖在与阴影对应的区域有积聚。经支气管肺活检未能给出明确诊断，因此由于怀疑肺癌而进行了开胸肺活检。进行了针吸活检，术中快速病理检查将肿瘤诊断为大细胞神经内分泌癌。由于肺门淋巴结采样未发现转移，因严重阻塞性肺疾病行左上叶切除术。免疫组织化学检查最终将肿瘤诊断为LCCNM。患者术后十个月情况良好，无复发。
