Bessho Toshiya, Yokochi Keiya, Sakurai Teruhisa
Department of Surgery, Wakayama National Hospital, Wakayama, Japan.
Jpn J Thorac Cardiovasc Surg. 2004 Sep;52(9):426-8. doi: 10.1007/s11748-004-0037-8.
We report a case of combined large cell neuroendocrine carcinoma. A 78-year-old man with vertigo was referred to our hospital where chest X-ray revealed a tumor shadow in the right lung. A transbronchial lung biopsy specimen verified a diagnosis of non-small cell lung carcinoma (cT1N0M0). Right lower lobectomy with mediastinal lymph node dissection (#7, 8, 9) was performed. A postoperative histological diagnosis was combined large cell neuroendocrine carcinoma of a component of squamous cell carcinoma [pT4 (pm) N2M0]. The patient received concurrent chemoradiotherapy due to upper mediastinal lymph node metastasis 4 months after surgery. The chemoradiotherapy well responded and the patient remains well 9 months after surgery.
我们报告一例合并大细胞神经内分泌癌的病例。一名78岁男性因眩晕被转诊至我院，胸部X线检查发现右肺有肿瘤阴影。经支气管肺活检标本确诊为非小细胞肺癌（cT1N0M0）。行右下肺叶切除术及纵隔淋巴结清扫术（第7、8、9组）。术后组织学诊断为合并大细胞神经内分泌癌成分的鳞状细胞癌[pT4（pm）N2M0]。患者术后4个月因上纵隔淋巴结转移接受同步放化疗。放化疗反应良好，术后9个月患者情况良好。
