Abe Kazuo, Hikita Tachio, Yokoe Masaru, Mihara Masahito, Sakoda Saburo
Department of Neurology, Graduate School of Medicine, Osaka University, Osaka, Japan.
J Neuroimaging. 2006 Jan;16(1):73-7. doi: 10.1177/1051228405279988.
Patients with multiple system atrophy (MSA) may show the "cross" sign in the pontine base that has been considered as an expression of the degeneration of pontine neurons and transverse pontocerebellar fibers. However, correlations between pontine base atrophy and existence of "cross" sign have not been fully investigated. The authors studied 68 patients with MSA (47 MSA-C [predominantly cerebellar ataxia], 21 MSA-P [predominantly parkinsonism], mean [+/-SD ] 58.7 +/- 10.9 years). T1-weighted (T1W) sagittal and axial images and T2-weighted (T2W) axial images were obtained for all patients and controls. To measure the areas of pontine basis and cerebellar vermis, the authors used midsagittal T1W images and analyzed a bit map transformed on a computer. They classified atrophy in the pontine base into 3 grades. There is significant correlation between atrophies of pontine base and existence of the cross sign. All patients with a smaller area of pontine base 2 standard deviations below those of normal controls had the cross sign. This supports that existence of the cross sign depends only on the extent of pontine base atrophies.
多系统萎缩（MSA）患者在脑桥基底部可能出现“十字”征，该征象被认为是脑桥神经元和脑桥横纤维变性的一种表现。然而，脑桥基底部萎缩与“十字”征的存在之间的相关性尚未得到充分研究。作者对68例MSA患者进行了研究（47例MSA-C型[以小脑性共济失调为主]，21例MSA-P型[以帕金森综合征为主]，平均[±标准差]年龄58.7±10.9岁）。为所有患者及对照组获取了T1加权（T1W）矢状位和轴位图像以及T2加权（T2W）轴位图像。为测量脑桥基底部和小脑蚓部的面积，作者使用矢状位T1W图像并在计算机上分析转换后的位图。他们将脑桥基底部萎缩分为3级。脑桥基底部萎缩与“十字”征的存在之间存在显著相关性。所有脑桥基底部面积比正常对照组低2个标准差的患者均有“十字”征。这支持了“十字”征的存在仅取决于脑桥基底部萎缩的程度。
