异喹啉衍生物作为潜在的乙酰胆碱酯酶抑制剂。
Isoquinoline derivatives as potential acetylcholinesterase inhibitors.
作者信息
Markmee Sutthatip, Ruchirawat Somsak, Prachyawarakorn Vilailak, Ingkaninan Kornkanok, Khorana Nantaka
机构信息
Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
出版信息
Bioorg Med Chem Lett. 2006 Apr 15;16(8):2170-2. doi: 10.1016/j.bmcl.2006.01.067. Epub 2006 Feb 17.
Several bisbenzylisoquinoline alkaloid derivatives showed the inhibitory activity at acetylcholinesterase enzyme (AChE) in micromolar range. It is possible that monomeric moiety of bisbenzylisoquinoline alkaloid might be required for acetylcholinesterase enzyme inhibition. AChE inhibitory activity of related monomeric 1-benzylisoquinolines was examined by using Ellman colorimetric assay with galanthamine as a reference standard.
几种双苄基异喹啉生物碱衍生物在微摩尔范围内显示出对乙酰胆碱酯酶（AChE）的抑制活性。双苄基异喹啉生物碱的单体部分可能是抑制乙酰胆碱酯酶所必需的。以加兰他敏为参比标准品，采用Ellman比色法检测了相关单体1-苄基异喹啉的AChE抑制活性。
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