Loirand Gervaise, Guérin Patrice, Pacaud Pierre
INSERM U-533-Institut du Thorax, Faculté des Sciences, Nantes, France.
Circ Res. 2006 Feb 17;98(3):322-34. doi: 10.1161/01.RES.0000201960.04223.3c.
Rho kinases (ROCKs) are the first and the best-characterized effectors of the small G-protein RhoA. In addition to their effect on actin organization, or through this effect, ROCKs have been found to regulate a wide range of fundamental cell functions such as contraction, motility, proliferation, and apoptosis. Abnormal activation of the RhoA/ROCK pathway has been observed in major cardiovascular disorders such as atherosclerosis, restenosis, hypertension, pulmonary hypertension, and cardiac hypertrophy. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of ROCK signaling and its roles in cardiovascular physiology and pathophysiology.
Rho激酶（ROCKs）是小G蛋白RhoA的首个也是特征最明确的效应器。除了对肌动蛋白组织有影响之外，或者说通过这种影响，人们发现ROCKs可调节多种基本的细胞功能，如收缩、运动、增殖和凋亡。在动脉粥样硬化、再狭窄、高血压、肺动脉高压和心脏肥大等主要心血管疾病中，均观察到RhoA/ROCK信号通路的异常激活。基于近期的分子、细胞和动物研究，本综述聚焦于对ROCK信号传导及其在心血管生理和病理生理中作用的当前认识。
