雄激素受体mRNA在人肝细胞癌及肝癌细胞系中的表达。

Expression of androgen receptor mRNA in human hepatocellular carcinomas and hepatoma cell lines.

作者信息

Nakagama H, Gunji T, Ohnishi S, Kaneko T, Ishikawa T, Makino R, Hayashi K, Shiga J, Takaku F, Imawari M

机构信息

Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Hepatology. 1991 Jul;14(1):99-102. doi: 10.1002/hep.1840140116.

DOI:10.1002/hep.1840140116

PMID:1648543

Abstract

The expression of androgen receptor messenger RNA in hepatocellular carcinomas and hepatoma cell lines was studied using Northern-blot analysis and the complementary DNA-polymerase chain reaction method. Androgen receptor messenger RNAs were detected (although in low levels) in both hepatocellular carcinoma tissues and noncancerous tissues of the liver in all eight cases we studied, except for the tumor sample of one case. None of the hepatoma cell lines studied, however, expressed detectable levels of androgen receptor messenger RNA except for the SK-HEP-1 hepatoma cell line.

摘要

采用Northern印迹分析和互补DNA聚合酶链反应方法，研究了雄激素受体信使核糖核酸在肝细胞癌及肝癌细胞系中的表达。在我们研究的所有8例病例中，除1例肿瘤样本外，肝细胞癌组织和肝脏非癌组织中均检测到雄激素受体信使核糖核酸（尽管水平较低）。然而，在所研究的肝癌细胞系中，除SK-HEP-1肝癌细胞系外，均未检测到可检测水平的雄激素受体信使核糖核酸。