Donaghy M, Rushworth G, Jacobs J M
Department of Clinical Neurology, Radcliffe Infirmary, Oxford, UK.
Neurology. 1991 Jul;41(7):1112-6. doi: 10.1212/wnl.41.7.1112.
A 58-year-old dental prosthetic technician developed generalized sensorimotor peripheral neuropathy. Neurophysiologic studies showed a generalized sensorimotor neuropathy of axonal degeneration type. Examination of a sural nerve biopsy showed a moderately severe axonal neuropathy with loss of large myelinated fibers and unmyelinated axons. There was evidence of slow ongoing degeneration and considerable fiber regeneration. Electron microscopy showed increased numbers of filaments in a few fibers. These findings show resemblances to the nerve changes caused by another acrylic resin, acrylamide. We suggest that the neuropathy may have been caused by 30 years of occupational cutaneous and inhalational exposure to methyl methacrylate monomer since we excluded other recognized causes of neuropathy.
一名58岁的牙科修复技师患上了全身性感觉运动性周围神经病变。神经生理学研究显示为轴索性变性型的全身性感觉运动性神经病变。对腓肠神经活检的检查显示为中度严重的轴索性神经病变，伴有大的有髓纤维和无髓轴突的丧失。有持续缓慢变性和大量纤维再生的证据。电子显微镜检查显示少数纤维中的细丝数量增加。这些发现与另一种丙烯酸树脂丙烯酰胺引起的神经变化相似。我们认为，由于排除了其他公认的神经病变原因，这种神经病变可能是由于30年职业性皮肤和吸入甲基丙烯酸甲酯单体所致。
