Tower C, Chappell S, Kalsheker N, Baker P, Morgan L
Division of Clinical Chemistry, Institute of Genetics, School of Molecular Medical Sciences, University Hospital, Nottingham, UK.
BJOG. 2006 Mar;113(3):335-9. doi: 10.1111/j.1471-0528.2005.00841.x.
In 2003, the angiotensinogen (AGT) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies (P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking (P = 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women.
2003年，人们发现血管紧张素原（AGT）基因与小于胎龄儿（SGA）有关。本研究纳入了107例受小于胎龄儿影响的妊娠和101例正常妊娠，旨在进一步研究这种关联。小于胎龄儿妊娠和正常妊娠之间的母体或胎儿AGT基因型或单倍型频率没有差异（P>0.35）。对正常妊娠母亲的数量性状分析表明，AGT单倍型与产前登记时的血压和体重指数之间存在关联（P=0.04），这表明AGT可能在健康孕妇体重与血压的复杂关系中起作用。
