Sosted Heidi, Johansen Jeanne Duus, Andersen Klaus Ejner, Menné Torkil
National Allergy Research Centre, Department of Dermatology, Gentofte Hospital, University of Copenhagen, 2900 Helleup, Denmark.
Contact Dermatitis. 2006 Feb;54(2):87-91. doi: 10.1111/j.0105-1873.2006.00746.x.
Serious adverse skin reactions to permanent hair dyes and temporary black tattoos have been reported. As temporary tattoos have become fashionable among adolescents, the risk profile for p-phenylenediamine (PPD) sensitization of the population has changed simultaneously with an increasing use of hair dyes in this age group. This investigation reports PPD sensitization in children with regard to cause of sensitization, clinical presentation and consequences. Clinical history and patch test results for consecutive children below 16 years of age with suspected hair dye allergic reactions and positive patch tests to PPD were collected over 2 years in 2 Danish dermatology clinics. 8 children aged 12-15 years were collected, and they all reacted to several hair dye ingredients. 5 of the patients were hospitalized, 1 in the intensive care unit. 6 of the patients gave a history of prior reaction to temporary black tattoos. These children showed simultaneous positive patch reactions to N-isopropyl-N-phenyl-p-phenylenediamine and local anaesthetics, while such reaction patterns were not seen in children with hair dye reactions only. The clinical consequences of these reactions are unknown. A re-evaluation of the risk assessment/risk management for hair dyes is required.
已有关于永久性染发剂和临时性黑色纹身引起严重皮肤不良反应的报道。随着临时性纹身在青少年中变得流行，随着该年龄组染发剂使用的增加，人群对对苯二胺（PPD）致敏的风险状况也同时发生了变化。本调查报道了儿童PPD致敏在致敏原因、临床表现及后果方面的情况。在丹麦的2家皮肤科诊所，对连续2年中16岁以下疑似染发剂过敏反应且对PPD斑贴试验呈阳性的儿童收集其临床病史和斑贴试验结果。共收集到8名12 - 15岁的儿童，他们均对多种染发剂成分有反应。其中5名患者住院治疗，1名入住重症监护病房。6名患者有对临时性黑色纹身既往反应史。这些儿童对N - 异丙基 - N - 苯基 - 对苯二胺和局部麻醉剂斑贴试验同时呈阳性反应，而仅对染发剂有反应的儿童未出现这种反应模式。这些反应的临床后果尚不清楚。需要对染发剂的风险评估/风险管理进行重新评估。
