随机试验的规划与实施中的问题。

Issues in the planning and conduct of randomised trials.

作者信息

Bhandari Mohit, Pape Hans C, Giannoudis Peter V

机构信息

Department of Orthopaedic Surgery, McMaster University, Canada.

出版信息

Injury. 2006 Apr;37(4):349-54. doi: 10.1016/j.injury.2006.02.002. Epub 2006 Feb 17.

DOI:10.1016/j.injury.2006.02.002

PMID:16487524

Abstract

Randomised trials top the hierarchy of evidence. To provide the best evidence to guide surgical practice, randomised trials must answer clinically important questions, have important and objective outcome measurement and be sufficiently powered to detect important differences between interventions. Investigators who adhere to these principles are more likely to succeed during the conduct of their trials.

摘要

随机试验在证据等级中处于最高层。为了提供最佳证据以指导外科手术实践，随机试验必须回答临床重要问题，具备重要且客观的结果测量方法，并有足够的效能来检测不同干预措施之间的重要差异。坚持这些原则的研究者在开展试验时更有可能取得成功。