Thilers Petra P, Macdonald Stuart W S, Herlitz Agneta
Aging Research Center, Division of Geriatric Epidemiology, NEUROTEC, Karolinska Institute,Stockholm, Sweden.
Psychoneuroendocrinology. 2006 Jun;31(5):565-76. doi: 10.1016/j.psyneuen.2005.12.005. Epub 2006 Feb 17.
The relationship between testosterone (T) and cognition has yielded conflicting evidence, showing both positive and negative influences of T on cognitive performance. The association between free testosterone (FT) and cognition was revisited in a large population-based sample of 1276 women and 1107 men (35-90 years of age), assessed individually on visuospatial, verbal fluency, semantic, and episodic memory tasks. For men, higher FT levels were associated with better visuospatial abilities, semantic memory, and episodic memory, with greater positive influence with increasing age. Statistical covariates included age, education, and select medications. For women, FT was negatively associated with verbal fluency, semantic memory, and episodic memory, although only verbal fluency was significant at conventional alpha levels. These results support the claim that FT exerts sex-specific influences on cognitive performance.
睾酮（T）与认知之间的关系已产生相互矛盾的证据，表明T对认知表现既有积极影响也有消极影响。在一个基于人群的大样本（1276名女性和1107名男性，年龄在35至90岁之间）中重新研究了游离睾酮（FT）与认知之间的关联，对他们分别进行了视觉空间、语言流畅性、语义和情景记忆任务的评估。对于男性，较高的FT水平与更好的视觉空间能力、语义记忆和情景记忆相关，且随着年龄增长这种积极影响更大。统计协变量包括年龄、教育程度和特定药物。对于女性，FT与语言流畅性、语义记忆和情景记忆呈负相关，尽管只有语言流畅性在传统的alpha水平上具有显著性。这些结果支持了FT对认知表现产生性别特异性影响这一观点。
