Discovery of novel hydroxy pyrazole based factor IXa inhibitor.

作者信息

Vijaykumar Dange, Sprengeler Paul A, Shaghafi Michael, Spencer Jeffrey R, Katz Brad A, Yu Christine, Rai Roopa, Young Wendy B, Schultz Brian, Janc James

机构信息

Celera, 180 Kimball Way, South San Francisco, CA 94080, USA.

出版信息

Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. doi: 10.1016/j.bmcl.2006.01.123. Epub 2006 Feb 17.

DOI:10.1016/j.bmcl.2006.01.123

PMID:16487703

Abstract

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

摘要

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