Chia S E, Chia K S, Phoon W H, Lee H P
Department of Community, Occupational & Family Medicine, National University of Singapore.
Scand J Work Environ Health. 1991 Jun;17(3):170-4. doi: 10.5271/sjweh.1720.
Of the 184 cases of silicosis registered between 1 January 1970 and 31 December 1984 in Singapore, all the relevant information was available for 159, which were linked to the population-based National Cancer Register for lung cancer. Nine cases of lung cancer were found. The standardized incidence ratio (SIR) was computed with the age- and calendar-specific incidence of lung cancer rates of Chinese males in Singapore as a basis. Excess risk of lung cancer was found (SIR 2.01, 95% confidence interval 0.92-3.81). Adjustment for smoking showed that it alone could not account for the excess lung cancer risk. There was an increasing, but not significant, trend with increasing severity of silicosis and exposure duration. The results suggest that the severity of silicosis and possibly exposure to free silica may have contributed to the excess of lung cancer among the cases of silicosis studied.
在1970年1月1日至1984年12月31日期间新加坡登记的184例矽肺病例中，159例可获取所有相关信息，这些病例与基于人群的国家肺癌登记册相关联。发现了9例肺癌。以新加坡中国男性按年龄和日历时间特定的肺癌发病率为基础计算标准化发病率（SIR）。发现存在肺癌超额风险（SIR 2.01，95%置信区间0.92 - 3.81）。对吸烟进行调整后表明，仅吸烟不能解释肺癌超额风险。随着矽肺严重程度和接触时长增加，存在上升趋势，但不显著。结果表明，矽肺的严重程度以及可能接触游离二氧化硅可能导致了所研究的矽肺病例中肺癌超额。
