Horvath Gyongyi, Kekesi Gabriella
Department of Physiology, Faculty of Medicine, University of Szeged, P.O. Box 427, H-6701 Szeged, Hungary.
Brain Res Rev. 2006 Aug 30;52(1):69-92. doi: 10.1016/j.brainresrev.2006.01.001. Epub 2006 Feb 20.
It is well known that a multitude of transmitters and receptors are involved in the nociceptive system, some of them increasing and others inhibiting the pain sensation both peripherally and centrally. These substances, which include neurotransmitters, hormones, etc., can modify the activity of nerves involved in the pain pathways. Furthermore, the organism itself can express very effective antinociception under different circumstances (e.g. stress), and, during such situations, the levels of various endogenous ligands change. A very exciting field of pain research relates to the roles of endogenous ligands. Most of them have been suggested to influence pain transmission, but only a few studies have been performed on the interactions of different endogenous ligands. This review focuses on the results of antinociceptive interactions after the co-administration of endogenous ligands. The data based on 55 situations reveal that the interactions between the endogenous ligands are very different, depending on the substances, the pain tests, the species of animals and the route of administrations. It is also revealed that only a few of the possible interactions between endogenous ligands have been investigated to date, in spite of the fact that the type of antinociceptive interaction between different endogenous ligands could hardly be predicted. The results indicate that the combination of endogenous ligands should not be omitted from the pain therapy arsenal. Attention will hopefully be drawn to the complex interdependence of endogenous ligands and their potential use in clinical practice.
众所周知，多种递质和受体参与伤害性感受系统，其中一些在外周和中枢增强痛觉，而另一些则抑制痛觉。这些物质包括神经递质、激素等，可改变参与疼痛通路的神经活动。此外，机体自身在不同情况下（如应激）可表现出非常有效的抗伤害感受，在此类情况下，各种内源性配体的水平会发生变化。疼痛研究中一个非常令人兴奋的领域涉及内源性配体的作用。大多数内源性配体被认为会影响疼痛传递，但关于不同内源性配体相互作用的研究却很少。本综述聚焦于内源性配体联合给药后的抗伤害感受相互作用结果。基于55种情况的数据表明，内源性配体之间的相互作用因物质、疼痛测试、动物种类和给药途径而异。还表明，尽管不同内源性配体之间的抗伤害感受相互作用类型很难预测，但迄今为止，仅对少数可能的相互作用进行了研究。结果表明，内源性配体的联合应用不应被排除在疼痛治疗手段之外。有望引起人们对内源性配体复杂的相互依存关系及其在临床实践中潜在用途的关注。
