人类巨细胞病毒的细胞受体。

Cellular receptor for human cytomegalovirus.

作者信息

Cooper N R, Nowlin D, Taylor H P, Compton T

机构信息

Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

出版信息

Transplant Proc. 1991 Jun;23(3 Suppl 3):56-9, discussion 59.

PMID:1648837

Abstract

The results of the studies reported strongly suggest that the binding of HCMV to a target cell in vitro is mediated by a glycoprotein membrane receptor having a molecular weight of approximately 30 kd. It has been further concluded that this particular molecule is the principal HCMV receptor, since it has been observed in each of the cell types that have been studied. As for the 28 and 60 kd molecules, the former may be a proteolytic degradation product and the latter a dimer of the 30 kd receptor. The precise contribution of the 92 kd that may allow for viral penetration into a host cell molecule to the initial recognition event is unknown at the present time.

摘要

所报道的研究结果有力地表明，人巨细胞病毒（HCMV）在体外与靶细胞的结合是由一种分子量约为30kd的糖蛋白膜受体介导的。进一步得出的结论是，这种特定分子是主要的HCMV受体，因为在已研究的每种细胞类型中都观察到了它。至于28kd和60kd的分子，前者可能是蛋白水解降解产物，后者是30kd受体的二聚体。目前尚不清楚92kd分子对病毒进入宿主细胞的初始识别事件的确切作用，该分子可能有助于病毒穿透宿主细胞。