Ronson Brian B, Yonemoto Les T, Rossi Carl J, Slater James M, Slater Jerry D
Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA 92354, USA.
Int J Radiat Oncol Biol Phys. 2006 Apr 1;64(5):1367-70. doi: 10.1016/j.ijrobp.2005.11.001. Epub 2006 Feb 20.
To evaluate patient tolerance of intrarectal balloons used during conformal prostate irradiation.
A retrospective analysis was performed on 3,561 patients who underwent conformal radiation for prostate cancer. Therapy consisted of proton irradiation of the prostate and seminal vesicles and X-ray treatment of the pelvis when warranted. The number of treatments in which the balloon was tolerated was recorded. Results were stratified according to method of irradiation (protons alone vs. combined proton/X-ray) and method of planning (2D vs. 3D planning of X-ray fields in patients undergoing combination treatment).
Of all the patients evaluated, 3,474 (97.6%) tolerated the balloon throughout treatment; 87 (2.4%) declined the balloon for 1 or more treatments and tolerated the balloon for 85.5% of their treatments. Chi-square analysis revealed a significant tolerance advantage in those who received protons alone compared with combination treatment (99.5% vs. 95.7%; p < 0.001). In patients undergoing combination treatment, chi-square analysis did not reveal significant tolerance differences in patients undergoing 3D vs. 2D planning for pelvic X-ray fields (95.74% vs. 95.72%; p = 0.990).
Intrarectal balloons are well tolerated over a course of conformal prostate irradiation.
评估在适形前列腺放疗期间使用直肠内球囊时患者的耐受性。
对3561例行前列腺癌适形放疗的患者进行回顾性分析。治疗包括对前列腺和精囊进行质子照射，并在必要时对骨盆进行X线治疗。记录患者耐受球囊的治疗次数。根据照射方法（单纯质子照射与质子/X线联合照射）和计划方法（联合治疗患者中X线野的二维与三维计划）对结果进行分层。
在所有评估的患者中，3474例（97.6%）在整个治疗过程中耐受球囊；87例（2.4%）在1次或更多次治疗中拒绝使用球囊，其治疗中有85.5%的次数耐受球囊。卡方分析显示，单纯接受质子照射的患者与联合治疗的患者相比，耐受性有显著优势（99.5%对95.7%；p<0.001）。在接受联合治疗的患者中，卡方分析未显示在盆腔X线野进行三维与二维计划的患者之间耐受性有显著差异（95.74%对95.72%；p = 0.990）。
在适形前列腺放疗过程中，直肠内球囊耐受性良好。
