Takeda M, Mizuguchi N, Ohyama Y, Suzuki S, Itoh M, Mukojima T, Kumagai T, Iwasaki H
Akita Medical Center, Division of Gastroenterology, Japan.
Gan To Kagaku Ryoho. 1991 Jul;18(8):1367-70.
A 63-year-old male with four intrahepatic recurrences of surgically resected hepatocellular carcinoma was admitted to our hospital in June 1985. He underwent lateral segmentectomy of the liver in November 1983. Pathologic finding of Edmondson II with liver cirrhosis had been confirmed by the operative specimen. Sizes of four recurrent tumors were assessed by CT as 3.5 x 2.2 cm, 2.6 x 2.2 cm, 2.2 x 2.2 cm and 2.2 x 2.2 cm, respectively. During five years until July 1990, the patient was treated with hepatic arterial infusion of Lipiodol-anticancer drug suspension eight times (total 5-FU 900 mg, ADM 77 mg, MMC 73 mg, and Lipiodol 36 ml) and hepatic arterial chemoembolization of MMC microcapsules one time. In addition, two hepatic arterial infusions of CDDP (total 70 mg) were given and 5-FU (total 10 g) was administered intravenously. Partial response (PR) was obtained for 19 months. Hepatic arterial infusion of Lipiodol-anticancer drug suspension was given only once every 6 months, and he maintained a good quality of life for over four and half years. The man died in July 1990. In general, multiple intrahepatic recurrence of surgical resected hepatocellular carcinoma has a poor prognosis. Therefore it was considered that hepatic arterial infusion of this drug brought about the relatively long survival of more than five years.
一名63岁男性，手术切除的肝细胞癌出现4次肝内复发，于1985年6月入住我院。他于1983年11月接受了肝脏左外叶切除术。手术标本证实为伴有肝硬化的 Edmondson II 级。通过CT评估，4个复发肿瘤的大小分别为3.5×2.2厘米、2.6×2.2厘米、2.2×2.2厘米和2.2×2.2厘米。在1990年7月之前的5年里，该患者接受了8次肝动脉注射碘油-抗癌药物混悬液（5-氟尿嘧啶总量900毫克、阿霉素77毫克、丝裂霉素73毫克、碘油36毫升）以及1次丝裂霉素微胶囊肝动脉化疗栓塞。此外，还进行了2次肝动脉注射顺铂（总量70毫克），并静脉注射了5-氟尿嘧啶（总量10克）。获得了19个月的部分缓解（PR）。肝动脉注射碘油-抗癌药物混悬液每6个月仅进行1次，他维持了超过四年半的良好生活质量。该男子于1990年7月去世。一般来说，手术切除的肝细胞癌出现多次肝内复发预后较差。因此，认为这种药物的肝动脉注射带来了超过5年的相对较长生存期。
