原子水平的癌症风险评估。
Cancer risk assessment at the atomic level.
作者信息
Monteiro Alvaro N A, Couch Fergus J
机构信息
Risk Assessment, Detection, and Intervention Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA.
出版信息
Cancer Res. 2006 Feb 15;66(4):1897-9. doi: 10.1158/0008-5472.CAN-05-3034.
Abstract
A flurry of articles on the structure of different domains of BRCA1 and BRCA2 have not only shed light on the biology of these proteins but have also raised hopes that these data could eventually be used to infer cancer association for a large number of inherited missense mutations whose effect on protein function is unclear.
摘要
一系列关于BRCA1和BRCA2不同结构域的文章不仅揭示了这些蛋白质的生物学特性，还燃起了人们的希望，即这些数据最终可用于推断大量对蛋白质功能影响不明的遗传性错义突变与癌症的关联。
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