Isolation and identification of hemin as an endogenous Na+/K(+)-ATPase inhibitor from porcine blood cells.
作者信息
Yasuhara T, Mori M, Wakamatsu K, Kubo K
机构信息
Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd., Japan.
出版信息
Biochem Biophys Res Commun. 1991 Jul 15;178(1):95-103. doi: 10.1016/0006-291x(91)91784-a.
PMID:1648917
Abstract
A substance which is a potent inhibitor of Na+/K(+)-ATPase activity and competitively displaces [3H]ouabain binding to this enzyme was isolated from porcine blood cells. From its chemical and physiochemical properties, this activity was identified as hemin (chloroprotohemin IX). Hemin showed a dose dependent curve for Na+/K(+)-ATPase inhibitory activity similar to that of ouabain and displaced [3H]ouabain binding as potent as 1/100 of ouabain itself.
摘要
Zotero 插件