Arican Ozer, Kurutas Ergul Belge, Sasmaz Sezai
Department of Dermatology, Kahramanmaras Sutcuimam Medical Faculty, Turkey.
Mediators Inflamm. 2005 Dec 14;2005(6):380-4. doi: 10.1155/MI.2005.380.
Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood of cases were measured spectrophotometrically. The values compared with control group, the relation between the severity and distribution of acne, and the correlation of each enzyme level were researched. CAT and G6PD levels in patients were found to be statistically decreased, and SOD and MDA levels were found to be statistically increased (P < .001). However, any statistical difference and correlation could not be found between the severity and distribution of lesions and the mean levels of enzymes. In addition, we found that each enzyme is correlated with one another. Our findings show that oxidative stress exists in the acne patients. It will be useful to apply at least one antioxidant featured drug along with the combined acne treatment.
寻常痤疮是常见的皮肤病之一，其发病机制是多因素的。在本研究中，我们旨在确定氧化应激在寻常痤疮中的作用。连续纳入了43例痤疮患者和46例对照。用分光光度法测量病例静脉血中过氧化氢酶（CAT）、葡萄糖-6-磷酸脱氢酶（G6PD）、超氧化物歧化酶（SOD）和丙二醛（MDA）等氧化应激参数。将这些值与对照组进行比较，研究痤疮严重程度和分布之间的关系以及各酶水平之间的相关性。发现患者的CAT和G6PD水平在统计学上降低，SOD和MDA水平在统计学上升高（P <.001）。然而，在皮损的严重程度和分布与酶的平均水平之间未发现任何统计学差异和相关性。此外，我们发现各酶之间相互关联。我们的研究结果表明痤疮患者存在氧化应激。在联合痤疮治疗中应用至少一种具有抗氧化特性的药物将是有益的。
