Mori K, Saitou Y, Tominaga K, Miyazawa N
Department of Thoracic Disease, Tochigi Cancer Center, Japan.
Eur J Cancer. 1991;27(6):729-32. doi: 10.1016/0277-5379(91)90175-d.
In order to decide the administration method of metoclopramide for prevention or control of chemotherapy-induced nausea and vomiting in multidrug chemotherapy, with cisplatin 5-day continuous intravenous infusion (25 mg/m2/day) for patients with advanced lung cancer, a randomised crossover study of intermittent bolus infusion (1 mg/kg, 30 min, every 8 h, day 1-5) and continuous infusion (3 mg/kg/24 h, 120 h) of metoclopramide was performed. Both regimens included methylprednisolone and diphenhydramine given concurrently. The acute and delayed antiemetic effects were examined. 21 cases could be evaluated. There were 6 and 10 cases (P = 0.048), respectively, of no nausea and no vomiting; 14 and 18 cases (P = 0.048), respectively, of no vomiting; and vomiting episodes were seen 27 and 9 times, respectively (P = 0.042). Thus, metoclopramide continuous infusion was significantly superior in antiemetic effect compared to bolus infusion. Neither method had any serious side-effects and both were safe.
为确定多药化疗中使用甲氧氯普胺预防或控制化疗引起的恶心和呕吐的给药方法，对晚期肺癌患者采用顺铂5天持续静脉输注（25mg/m²/天），进行了一项甲氧氯普胺间歇推注（1mg/kg，30分钟，每8小时一次，第1 - 5天）和持续输注（3mg/kg/24小时，120小时）的随机交叉研究。两种方案均同时给予甲泼尼龙和苯海拉明。检查急性和延迟性止吐效果。21例患者可进行评估。无恶心且无呕吐的分别有6例和10例（P = 0.048）；无呕吐的分别有14例和18例（P = 0.048）；呕吐发作次数分别为27次和9次（P = 0.042）。因此，甲氧氯普胺持续输注的止吐效果明显优于推注。两种方法均无严重副作用，且都安全。
