慢性乙型肝炎病毒感染患者血清可溶性白细胞介素-2受体水平及其与抗-HBc的关系。
Serum soluble interleukin-2 receptor levels in patients with chronic hepatitis B virus infection and its relation with anti-HBc.
作者信息
Xiao Ping, Chen Qing-Feng, Yang Yan-Ling, Guo Zhen-Hua, Chen Hong
机构信息
Institute of Infectious Diseases, the First Hospital of Lanzhou University, 1 West Donggang Road, Lanzhou 730000, Gansu Province, China.
出版信息
World J Gastroenterol. 2006 Jan 21;12(3):482-4. doi: 10.3748/wjg.v12.i3.482.
AIM
To investigate the relationship between serum soluble interleukin-2 receptor (sIL-2R) level and anti-HBc in patients with chronic hepatitis B virus (HBV) infection.
METHODS
Sera from 100 patients with chronic HBV infection and 30 healthy controls were included in this study. The patients were divided into group A [HBsAg (+), HBeAg (+) and anti-HBc (+), n=50] and group B [HBsAg (+), HBeAg (+) and anti-HBc (-), n=50]. sIL-2R levels were determined using ELISA. HBV DNA and alanine aminotransferase (ALT) were also detected.
RESULTS
Serum sIL-2R levels were significantly higher in patients with chronic HBV infection than in healthy controls. Moreover, serum sIL-2R levels were significantly higher in patients with HBsAg (+), HBeAg (+) and anti-HBc (+) (976.56+/-213.51x10(3) U/L) than in patients with HBsAg (+), HBeAg (+) and anti-HBc (-) (393.41+/-189.54x10(3) U/L, P<0.01). A significant relationship was found between serum sIL-2R and ALT levels (P<0.01) in patients with chronic HBV infection, but there was no correlation between sIL-2R and HBV DNA levels. The anti-HBc status was significantly related to the age of patients (P<0.01).
CONCLUSION
The high sIL-2R level is related to positive anti-HBc in chronic hepatitis B patients. Positive anti-HBc may be related to T-lymphocyte activation and negative anti-HBc may imply immune tolerance in these patients.
目的
探讨慢性乙型肝炎病毒（HBV）感染患者血清可溶性白细胞介素-2受体（sIL-2R）水平与抗-HBc之间的关系。
方法
本研究纳入了100例慢性HBV感染患者的血清和30例健康对照者的血清。患者被分为A组[HBsAg(+)、HBeAg(+)和抗-HBc(+)，n = 50]和B组[HBsAg(+)、HBeAg(+)和抗-HBc(-)，n = 50]。采用酶联免疫吸附测定法（ELISA）测定sIL-2R水平。同时检测HBV DNA和丙氨酸氨基转移酶（ALT）。
结果
慢性HBV感染患者的血清sIL-2R水平显著高于健康对照者。此外，HBsAg(+)、HBeAg(+)和抗-HBc(+)患者的血清sIL-2R水平（976.56±213.51x10(3) U/L）显著高于HBsAg(+)、HBeAg(+)和抗-HBc(-)患者（393.41±189.54x10(3) U/L，P<0.01）。在慢性HBV感染患者中，血清sIL-2R与ALT水平之间存在显著相关性（P<0.01），但sIL-2R与HBV DNA水平之间无相关性。抗-HBc状态与患者年龄显著相关（P<0.01）。
结论
慢性乙型肝炎患者中sIL-2R水平升高与抗-HBc阳性有关。抗-HBc阳性可能与T淋巴细胞激活有关，而抗-HBc阴性可能意味着这些患者存在免疫耐受。
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