[慢性乙型肝炎患儿血清白细胞介素-2及可溶性白细胞介素-2受体浓度]

[Serum IL-2 and sIL-2R concentration in children with chronic hepatitis B].

作者信息

Pawłowska Małgorzata, Halota Waldemar, Smukalska Ewa, Grabczewska Edyta

机构信息

Katedra i Klinika Chorób Zakaźnych Akademii Medycznej w Bydgoszczy.

出版信息

Pol Merkur Lekarski. 2005 Jan;18(103):33-5.

PMID:15859543

Abstract

UNLABELLED

The aim of the study was evaluation of serum IL-2 and sIL-2R concentration in children with chronic hepatitis B without previous treatment.

MATERIAL AND METHODS

Investigations were performed on sera from 27 children, 13 HBsAg and HBeAg positive (group I) and 14 HBsAg positive, HBeAg negative, anti-HBe positive (group II). Serum IL-2 and sIL-2R concentrations were detected with ELISA method.

RESULTS

In all examined children serum IL-2 concentrations were decreased. The mean values of sIL-2R in group I was 4,40 (from 1,78 to 15,74) and in group II was 2,60 ( from 1,59 to 4,81) ng/ ml and were statistically significant higher in HBeAg positive children (group I, p < 0.005). The mean ALT activity in this group of children was increased (mean 74 U/I) . The positive correlation between sIL-2R and ALT activity was observed in group I.

CONCLUSIONS

In children with chronic hepatitis B a deficiency of Th1 mediated immunological response was observed. HBeAg/anti-HBe seroconversion seems to change the IL-2/sIL-2R balance.

摘要

未标记

本研究的目的是评估未经治疗的慢性乙型肝炎患儿血清白细胞介素-2（IL-2）和可溶性白细胞介素-2受体（sIL-2R）的浓度。

材料与方法

对27名儿童的血清进行检测，其中13名乙肝表面抗原（HBsAg）和乙肝e抗原（HBeAg）阳性（I组），14名HBsAg阳性、HBeAg阴性、乙肝e抗体（抗-HBe）阳性（II组）。采用酶联免疫吸附测定（ELISA）法检测血清IL-2和sIL-2R浓度。

结果

在所有接受检查的儿童中，血清IL-2浓度均降低。I组sIL-2R的平均值为4.40（范围1.78至15.74），II组为2.60（范围1.59至4.81）ng/ml，HBeAg阳性儿童（I组）的sIL-2R浓度在统计学上显著更高（p<0.005）。该组儿童的谷丙转氨酶（ALT）平均活性升高（平均74 U/I）。I组中观察到sIL-2R与ALT活性之间呈正相关。