Jaworski Radoslaw, Jastrzebski Tomasz, Swierblewski Maciej, Drucis Kamil, Kobierska-Gulida Grazyna
Klinika Chirurgii Onkologicznej Akademii Medycznej w Gdansku, Debinki 7, 80-211 Gdansk, Poland.
World J Gastroenterol. 2006 Jan 28;12(4):665-7. doi: 10.3748/wjg.v12.i4.665.
Malignant gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors originating from the wall of the gastrointestinal tract. Their coexistence with other tumors originating from other germ layers is unique. We have reported a case of a 63-year-old GIST patient presenting as an epigastric mass associated with hepatic tumor. Histologically, the mesenteric tumor was composed of spindle cells showing both neural and smooth muscle differentiation. Immunohistochemical examination showed positive staining for CD117, vimentin, S-100, and SMA, while CD34 antigen was negative. The hepatic tumor was diagnosed as hepatocellular carcinoma (HCC). To the best of our knowledge, this is the first case of GIST and HCC coexistence. The rarity of the case, however, should not lead to ignoring such a possibility in differential diagnosis.
恶性胃肠道间质瘤（GIST）是起源于胃肠道壁的罕见间叶组织肿瘤。它们与源自其他胚层的其他肿瘤并存的情况很独特。我们报告了一例63岁的GIST患者，表现为上腹部肿块并伴有肝肿瘤。组织学上，肠系膜肿瘤由显示神经和平滑肌分化的梭形细胞组成。免疫组织化学检查显示CD117、波形蛋白、S-100和SMA呈阳性染色，而CD34抗原呈阴性。肝肿瘤被诊断为肝细胞癌（HCC）。据我们所知，这是首例GIST与HCC并存的病例。然而，该病例的罕见性不应导致在鉴别诊断中忽视这种可能性。
