Suzuki Takeshi, Matsuo Keitaro, Ito Hidemi, Sawaki Akira, Hirose Kaoru, Wakai Kenji, Sato Shigeki, Nakamura Tsuneya, Yamao Kenji, Ueda Ryuzo, Tajima Kazuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Am J Med. 2006 Mar;119(3):217-24. doi: 10.1016/j.amjmed.2005.10.003.
Treatment failure for Helicobacter pylori (H. pylori) eradication is encountered in approximately 10-20% of patients, and many studies have pointed to a link with smoking. To investigate the effects of smoking on eradication outcome, we performed a meta-analysis.
A PubMed search was performed to retrieve articles published up to August 2005. Pooled odds ratio (OR) and differences rate for H. pylori eradication failure in smokers compared with nonsmokers were used as summary statistics. Meta-regression was used for examining the source of heterogeneity.
Twenty-two published studies (5538 patients), which provided information on eradication failure according to smoking status, were included in the analysis. The summary OR for eradication failure among smokers relative to nonsmokers was 1.95 (95% confidence interval [CI]: 1.55-2.45; P <.01). It corresponds with the differences in eradication rates between smokers and nonsmokers (8.4% [95% CI: 3.3-13.5%, P <.01]). Meta-regression analysis demonstrated that a high proportion of nonulcer dyspepsia patients in studies revealed a higher failure rate among smokers, compared with a low proportion of nonulcer dyspepsia.
Our meta-analysis demonstrated that smoking increases the treatment failure rate for H. pylori eradication.
幽门螺杆菌（H. pylori）根除治疗失败在约10%-20%的患者中出现，许多研究指出这与吸烟有关。为研究吸烟对根除结果的影响，我们进行了一项荟萃分析。
在PubMed上进行检索，以获取截至2005年8月发表的文章。将吸烟者与非吸烟者相比幽门螺杆菌根除失败的合并比值比（OR）和差异率用作汇总统计量。采用Meta回归分析来检查异质性来源。
分析纳入了22项已发表研究（5538例患者），这些研究提供了根据吸烟状况的根除失败信息。吸烟者相对于非吸烟者根除失败的汇总OR为1.95（95%置信区间[CI]：1.55-2.45；P<.01）。这与吸烟者和非吸烟者之间根除率的差异（8.4%[95%CI：3.3-13.5%，P<.01]）相符。Meta回归分析表明，研究中高比例的非溃疡性消化不良患者显示吸烟者的失败率高于低比例非溃疡性消化不良患者。
我们的荟萃分析表明，吸烟会增加幽门螺杆菌根除治疗的失败率。
