Neumayer Thomas, Findl Oliver, Buehl Wolf, Georgopoulos Michael
Department of Ophthalmology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
Am J Ophthalmol. 2006 Mar;141(3):517-523. doi: 10.1016/j.ajo.2005.11.019.
To observe and document the daily changes in the morphology of Elschnig pearls.
A prospective cohort study.
Twenty-nine pseudophakic eyes with pronounced, regeneratory posterior capsule opacification (PCO) were included in this prospective study. Retroillumination images were taken at days 0, 1, 2, and 14. A square grid was laid over the images. Increase, decrease, appearance, and disappearance of pearls between the follow-up images were quantified.
A total of 1371 areas (mean: 53/eye) of 26 eyes were analyzed between days 0 and 1 and 1 and 2, and 896 areas (50/eye) of 18 eyes between days 0 and 14. Between days 0 and 1, days 1 and 2, and days 0 and 14, we observed "no change" in pearl size in 72%, 77%, and 32%, a "minor increase" in 16%, 14%, and 10%, a "major increase" in 4%, 3%, and 42%, a "minor decrease" in 14%, 11%, and 11%, and a "major decrease" in 4%, 3%, and 37%, respectively. Appearance of newly formed pearls was found in 1%, 1%, and 9% and disappearance of pearls in 1%, 1%, and 5%, respectively.
Significant changes in the morphology of Elschnig pearls were observed within time intervals of only 24 hours. Appearance and disappearance of pearls, as well as progression and regression of pearls within these short intervals illustrate the dynamic behavior of regeneratory PCO. These findings may contribute to a better understanding of PCO and have implications on pharmaceutical interventions for PCO.
观察并记录Elschnig珠形态的每日变化。
前瞻性队列研究。
本前瞻性研究纳入了29只出现明显再生性后囊混浊（PCO）的人工晶状体眼。在第0天、第1天、第2天和第14天拍摄后照图像。在图像上覆盖方格网。对随访图像之间Elschnig珠的增加、减少、出现和消失情况进行量化。
在第0天与第1天以及第1天与第2天之间，对26只眼的总共1371个区域（平均每只眼53个区域）进行了分析，在第0天与第14天之间，对18只眼的896个区域（平均每只眼50个区域）进行了分析。在第0天与第1天、第1天与第2天以及第0天与第14天之间，我们观察到珠大小“无变化”的比例分别为72%、77%和32%，“轻微增加”的比例分别为16%、14%和10%，“显著增加”的比例分别为4%、3%和42%，“轻微减少”的比例分别为14%、11%和11%，“显著减少”的比例分别为4%、3%和37%。新形成的珠出现的比例分别为1%、1%和9%，珠消失的比例分别为1%、1%和5%。
仅在24小时的时间间隔内就观察到Elschnig珠形态有显著变化。在这些短时间间隔内珠的出现和消失，以及珠的进展和消退说明了再生性PCO的动态行为。这些发现可能有助于更好地理解PCO，并对PCO的药物干预有启示意义。
