小动物先天性心脏病：第二部分。基于人类遗传学研究的潜在遗传病因。

Congenital heart diseases in small animals: part II. Potential genetic aetiologies based on human genetic studies.

作者信息

Hyun Changbaig, Park In-Chul

机构信息

Victor Chang Cardiac Research Institute, St. Vincent Hospital, 384 Victoria Street, Darlinghurst, NSW 2010, Australia.

出版信息

Vet J. 2006 Mar;171(2):256-62. doi: 10.1016/j.tvjl.2005.02.007.

DOI:10.1016/j.tvjl.2005.02.007

PMID:16490707

Abstract

Comparative genetics provides veterinary researchers and clinicians with invaluable information for the understanding the possible genetic aetiologies and the disease process in congenital heart defects (CHDs) of dogs and cats. Although, the demand on this type of research has increased in the veterinary field, to date no fundamental genetic studies have been reported in the veterinary literature. In this second part of a two-part review, the general features and pathogenesis of major CHDs in humans and small animals are discussed. In addition, the known genetic aetiologies in human CHDs have been considered in parallel to CHDs in small animals.

摘要

比较遗传学为兽医研究人员和临床医生提供了宝贵信息，有助于理解犬猫先天性心脏缺陷（CHD）可能的遗传病因及疾病过程。尽管兽医领域对这类研究的需求有所增加，但迄今为止，兽医文献中尚未报道过基础遗传学研究。在这篇分两部分的综述的第二部分中，我们将讨论人类和小型动物主要CHD的一般特征和发病机制。此外，还将人类CHD已知的遗传病因与小型动物的CHD进行了对比分析。