Fleming S
Department of Pathology, University of Edinburgh, U.K.
J Pathol. 1991 Jun;164(2):95-100. doi: 10.1002/path.1711640202.
The differentiated function of epithelial tissues is dependent on the molecules which mediate the cohesion and polarization of the epithelium. Separate molecular families are responsible for the adhesion between adjacent cells and the adhesion between cells and the substratum. Using the kidney as a model of epithelial differentiation it has been shown that the assembly of a basal lamina containing the glycoprotein laminin and cadherin mediated intercellular adhesion are key events. The Wilms' tumour anti-oncogene plays a regulatory role in renal epithelial differentiation. Tissue modeling and tumour formation are both accompanied by reduced cell adhesion molecule function.
上皮组织的分化功能取决于介导上皮细胞黏附和极化的分子。不同的分子家族分别负责相邻细胞之间的黏附以及细胞与基底之间的黏附。以肾脏作为上皮分化的模型研究发现，包含糖蛋白层粘连蛋白的基底膜的组装以及钙黏蛋白介导的细胞间黏附是关键事件。肾母细胞瘤抑癌基因在肾上皮分化中起调节作用。组织建模和肿瘤形成均伴随着细胞黏附分子功能的降低。
