Schaar Johannes A, de Korte Chris L, Mastik Frits, van Damme Luc C A, Krams Rob, Serruys Patrick W, van der Steen Anton F W
Erasmus University, Rotterdam, The Netherlands.
Herz. 2005 Mar;30(2):125-33. doi: 10.1007/s00059-005-2642-4.
Rupture of thin-cap fibroatheroma is a major cause of acute myocardial infarction and stroke. Identification of these plaques is one of the major challenges in cardiovascular medicine. At present, techniques with sufficient sensitivity and specificity to identify these unstable plaques are not clinically available. This paper describes a new technique to identify these plaques.
Three-dimensional intravascular ultrasound palpography is a catheter-based technique that visualizes radial strain (deformation) of vascular tissue induced by physiological variations in intraluminal pressure. A three-dimensional palpogram of these cross sections can be constructed by performing a continuous pullback of the catheter. Phantom and animal experiments revealed feasibility and good reproducibility of three-dimensional palpography. Increased strain values were observed in areas with reduced cap thickness and increased macrophage accumulation. In patients (n = 2) three-dimensional palpography is feasible and identifies areas with high and low strain.
Three-dimensional palpography allows scanning of coronary arteries in patients to identify and localize highly deformable regions.
薄帽纤维粥样斑块破裂是急性心肌梗死和中风的主要原因。识别这些斑块是心血管医学面临的主要挑战之一。目前，临床上尚无具有足够敏感性和特异性来识别这些不稳定斑块的技术。本文介绍了一种识别这些斑块的新技术。
三维血管内超声触诊法是一种基于导管的技术，可显示由管腔内压力的生理变化引起的血管组织的径向应变（变形）。通过对导管进行连续回撤，可以构建这些横截面的三维触诊图。模型和动物实验揭示了三维触诊法的可行性和良好的可重复性。在帽厚度减小和巨噬细胞积聚增加的区域观察到应变值升高。在患者（n = 2）中，三维触诊法是可行的，并且可以识别高应变和低应变区域。
三维触诊法可对患者的冠状动脉进行扫描，以识别和定位高度可变形区域。
