Sajiki Hironao, Mori Akinori, Mizusaki Tomoteru, Ikawa Takashi, Maegawa Tomohiro, Hirota Kosaku
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan.
Org Lett. 2006 Mar 2;8(5):987-90. doi: 10.1021/ol060045q.
A Pd/C-catalyzed deoxygenation method of phenolic hydroxyl groups via aryl triflates or mesylates using Mg metal in MeOH at room temperature was developed. The addition of NH4OAc dramatically affects the reactivity and reaction rate. This method is particularly attractive to provide an environmentally benign and widely applicable removal method of phenolic alcohols under quite mild reaction conditions.
开发了一种在室温下于甲醇中使用镁金属通过芳基三氟甲磺酸酯或甲磺酸酯对酚羟基进行钯/碳催化脱氧的方法。加入醋酸铵会显著影响反应活性和反应速率。该方法特别吸引人之处在于，在相当温和的反应条件下提供了一种环境友好且广泛适用的酚醇去除方法。
