Nagata Koji, Sasaki Eun, Goda Koshi, Yamamoto Naomune, Sugino Masakazu, Yamamoto Kazuhiro, Narabayashi Isamu, Hanafusa Toshiaki
First Department of Internal Medicine, Osaka Medical College, Japan.
Clin Physiol Funct Imaging. 2006 Mar;26(2):92-8. doi: 10.1111/j.1475-097X.2006.00654.x.
We previously showed that diabetes contributes to the development of sclerotic lesions in cerebral arteries. In this study, we attempted to clarify whether differences in heart rate variability in non-hypertensive diabetic patients were dependent on the presence or absence of underlying cerebrovascular disease. Thirty diabetic subjects between 40 and 59 years of age and who had no prior history of hypertension were used in this study. Lacunar lesions (LA) were detected with magnetic resonance imaging and atherosclerotic lesions (AS) were detected using intra- and extracranial magnetic resonance angiography, and by ultrasonographic scanning of the carotid artery. Patients underwent a full clinical laboratory screening and a power spectrum analysis of their heart rate variability. Subjects were divided into two groups: those with and without LA. The low frequency/high frequency ratio (LF/HF ratio) was found to be significantly increased (P<0.01) in subjects with LA (2.2 +/- 0.3) compared to those without LA (1.3 +/- 0.1). When subjects were divided into groups based on their presence or absence of AS, high-frequency power was found to be significantly reduced (P<0.05) in the subjects with AS (12.8 +/- 3.4 ms) compared to those without AS (19.4 +/- 1.7 ms). The LF/HF ratio was found to be significantly increased (P<0.05) in the subjects with AS (2.2 +/- 0.3) compared to those without AS (1.4 +/- 0.1). Our data suggested that atherosclerotic lesions in cerebrovascular diseased linked to decrease of vagal nerve activity in non-hypertensive diabetic patients.
我们之前的研究表明，糖尿病会促使脑动脉发生硬化性病变。在本研究中，我们试图阐明非高血压糖尿病患者心率变异性的差异是否取决于是否存在潜在的脑血管疾病。本研究纳入了30名年龄在40至59岁之间且无高血压病史的糖尿病患者。通过磁共振成像检测腔隙性脑梗死（LA），并使用颅内和颅外磁共振血管造影以及颈动脉超声扫描检测动脉粥样硬化病变（AS）。患者接受了全面的临床实验室筛查以及心率变异性的功率谱分析。受试者被分为两组：有LA组和无LA组。与无LA组（1.3±0.1）相比，有LA组（2.2±0.3）的低频/高频比值（LF/HF比值）显著升高（P<0.01）。当根据是否存在AS将受试者分组时，与无AS组（19.4±1.7毫秒）相比，有AS组（12.8±3.4毫秒）的高频功率显著降低（P<0.05）。与无AS组（1.4±0.1）相比，有AS组（2.2±0.3）的LF/HF比值显著升高（P<0.05）。我们的数据表明，脑血管疾病中的动脉粥样硬化病变与非高血压糖尿病患者迷走神经活动的降低有关。
