Kuritzky L, Rosenberg M T, Sadovsky R
Department of Community Health and Family Medicine,University of Florida College of Medicine, Gainesville, FL, USA.
Int J Clin Pract. 2006 Mar;60(3):351-8. doi: 10.1111/j.1368-5031.2005.00830.x.
Benign prostatic hyperplasia (BPH) is a common disorder in ageing men. Patients with BPH often present with bothersome irritative and obstructive lower urinary tract symptoms -- urgency, frequency, nocturia, feeling of insufficient bladder emptying and weak or intermittent flow. alpha(1)-Blockers are the most frequently prescribed oral medications for the first-line treatment of the symptoms associated with BPH. Alfuzosin is a uroselective alpha(1)-blocker that relaxes the smooth muscle of the bladder neck and prostate gland to alleviate BPH symptoms. A pooled analysis of three phase III trials confirmed that treatment with alfuzosin 10 mg q.d. significantly improves the peak urinary flow rate and symptom severity compared with placebo treatment. Unlike some other alpha(1)-blockers, alfuzosin 10 mg q.d. is associated with a low incidence of sexual and vasodilatory side effects. Based on the clinical trials reviewed, alfuzosin 10 mg q.d. is an effective and well-tolerated treatment for the urinary symptoms associated with BPH.
良性前列腺增生（BPH）是老年男性的常见疾病。BPH患者常出现令人困扰的刺激性和梗阻性下尿路症状——尿急、尿频、夜尿、膀胱排空不全感以及尿流无力或间断。α1受体阻滞剂是治疗BPH相关症状最常用的一线口服药物。阿夫唑嗪是一种尿路选择性α1受体阻滞剂，可松弛膀胱颈和前列腺的平滑肌，以缓解BPH症状。三项III期试验的汇总分析证实，与安慰剂治疗相比，每日一次服用10 mg阿夫唑嗪可显著提高最大尿流率并改善症状严重程度。与其他一些α1受体阻滞剂不同，每日一次服用10 mg阿夫唑嗪的性副作用和血管舒张副作用发生率较低。基于所回顾的临床试验，每日一次服用10 mg阿夫唑嗪是治疗BPH相关尿路症状的一种有效且耐受性良好的疗法。
