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Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.

作者信息

Townsend L B, Drach J C, Wotring L L, Vittori S, Pudlo J S, Swayze E E, Gupta P, Maruyama T, Saxena N, Coleman L A

机构信息

Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor.

出版信息

Farmaco. 1991 Jan;46(1 Suppl):113-39.

PMID:1649609
Abstract
摘要

相似文献

1
Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents.某些吡咯并[2,3-d]嘧啶核苷及结构相关类似物作为潜在抗肿瘤和抗病毒药物的设计、合成及其构效关系研究
Farmaco. 1991 Jan;46(1 Suppl):113-39.
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Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines.丰加霉素、桑吉瓦霉素和硫代桑吉瓦霉素的非核苷类似物的合成：某些4-和4,6-取代基对吡咯并[2,3-d]嘧啶抗病毒活性的影响。
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Synthesis and Anti-HCV Activity of 4-Methoxy-7H-Pyrrolo[2,3-d] Pyrimidine Carbocyclic Nucleosides.4-甲氧基-7H-吡咯并[2,3-d]嘧啶碳环核苷的合成及其抗丙型肝炎病毒活性
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Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.某些与丰加霉素和桑吉瓦霉素相关的7-[(2-羟基乙氧基)甲基]吡咯并[2,3-d]嘧啶核苷的合成、细胞毒性及抗病毒活性
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Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides.核苷与核苷酸。185. 4'α-C-支链糖嘧啶核苷的合成及生物活性
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Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues.一些无环和C-无环吡咯并[2,3-d]嘧啶核苷类似物的合成及抗病毒活性
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Nonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirus.具有独特抗人巨细胞病毒作用机制的非核苷吡咯并嘧啶类化合物。
Antimicrob Agents Chemother. 1999 Aug;43(8):1888-94. doi: 10.1128/AAC.43.8.1888.